IMPACT OF STAIN NORMALIZATION AND PATCH SELECTION ON THE PERFORMANCE OF CONVOLUTIONAL NEURAL NETWORKS IN HISTOLOGICAL BREAST AND PROSTATE CANCER CLASSIFICATION

Impact of stain normalization and patch selection on the performance of convolutional neural networks in histological breast and prostate cancer classification

Background: Recently, deep learning has rapidly become the methodology of choice in digital pathology image analysis.However, due to the current challenges of digital pathology (color stain variability, large images, etc.), specific pre-processing steps are required to train a reliable deep learning model.Method: In this work, there are two main go

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Rodent Area Prostriata Converges Multimodal Hierarchical Inputs and Projects to the Structures Important for Visuomotor Behaviors

Area prostriata is a limbic structure critical to fast processing of moving stimuli in far peripheral visual field.Neural substrates underlying this function Tread Belt remain to be discovered.Using both retrograde and anterograde tracing methods, the present study reveals that the prostriata in rat and mouse receives inputs from multimodal hierarc

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Legacy parasite collections reveal species-specific population genetic patterns among three species of zoonotic schistosomes

Abstract Studies estimating genetic diversity and population structure in multi-host parasites are often constrained by temporally and spatially limited sampling.This study addresses these limitations by Display Figure analyzing globally distributed samples of three congeneric avian schistosomes (Trematoda: Schistosomatidae: Trichobilharzia), inclu

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Pre-existing minor variants with NS5A L31M/V-Y93H double substitution are closely linked to virologic failure with asunaprevir plus daclatasvir treatment for genotype 1b hepatitis C virus infection.

BackgroundL31 and Y93 in the NS5A region of the hepatitis C virus (HCV) are the most important substitution positions associated with resistance to Air Conditioner direct-acting antiviral (DAA) treatment.MethodsWe analyzed the frequency of NS5A L31M/V and Y93/H in NS5A inhibitor-naive HCV genotype 1 patients who received asunaprevir plus daclatasvi

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